2010-01-01 · Individual variations in thiopurine (TP) metabolism may affect both drug efficacy and toxicity. Our aim was to investigate the utility of thiopurine methyltransferase (TPMT) as well as thioguanine nucleotide (TGN) and methylthioinosine monophosphate (meTIMP) metabolite measurements with regard to clinical outcome.
For clinicians considering thiopurine drug therapy, ARUP offers a full menu of testing to support patient care. test code test name 0092066 Thiopurine Methyltransferase, RBC •Phenotype test that assesses risk for severe bone Thiopurine Methyltransferase, RBC: Reference Test Number: 0092066. Instructions: Send out Monday - Friday with the ARUP courier. Thiopurine drug therapy is used for autoimmune diseases, inflammatory bowel disease, acute lymphoblastic leukemia, and to prevent rejection after solid organ transplant. The inactivation of thiopurine drugs is catalyzed in part by thiopurine methyltrasferase (TPMT) and nudix hydrolase 15 (NUDT15). Help prevent hepatotoxicity from thiopurine therapy. This test helps identify individuals at increased risk of hepatotoxicity from thiopurine dose escalation.
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TPMT catalyzes the S-methylation of aromatics and heterocyclic sulfhydryl compounds, including medications, such as mercaptopurine, thioguanine, and azathioprine (Elion, 1989). 2018-02-22 Thiopurine methyltransferase (TPMT) produces inactive metabolites of azathioprine and, in humans, has a variable amount of activity. Humans with low TPMT activity commonly develop myelotoxicity when receiving azathioprine. Our study sought to characterize the distribution of TPMT activity in a population of dogs and to determine whether the pretreatment knowledge of red blood cell (RBC) TPMT 2001-11-01 human red blood cell (RBC) thiopurine methyltransferase (TPMT) activity. Genet Hartl DL and Clark AG (1997) Principles of Population Genetics, 3rd ed., pp 95–107, Epidemiol 12:1–11.
Thiopurine Methyltransferase: 79713-4: 510751: TPMT Activity: Units/mL RBC: 21563-2: 510750: Thiopurine Methyltransferase: 79713-4: 510752: Interpretation: 79713-4: 510750: Thiopurine Methyltransferase: 79713-4: 510754: Methodology: 49549-9
The recommended screening test for azathioprine and 6-mercaptopurine induced leucopenia is Thiopurine Methyltransferase Phenotyping (RBC) (test code: TPMP). Test performed at: Health Sciences Centre by DSM Biochemical Genetics Laboratory using an enzyme activity assay with the product detected by UPLC/fluorescence.
Sunrise Clinical Manager (SCM) Orderable: Thiopurine Methyltransferase (TPMT) Enzy. AllScripts (AEHR) Orderable: TPMT Enzyme. Reference Values • Normal: 15.1−26.4 units/mL RBC • Heterozygous for low TPMT variant: 6.3−15.0 units/mL RBC • Homozygous for low TPMT variant:
This test helps identify individuals at increased risk of hepatotoxicity from thiopurine dose escalation.
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These drugs, which include 6-thioguanine, 6-mercaptopurine, and azathioprine, inhibit (suppress) the body's immune system.
Thiopurine drugs are used to treat some
Thiopurine S-Methyltransferase (TPMT) Genotype - Thiopurine S-methyltransferase (TPMT; S-adenosyl-L-methionine:thiopurine S-methyltransferase) catalyzes thiopurine S-methylation, an important metabolic pathway for antineoplastic and immunosuppressive drugs. THIOPURINE METHYLTRANSFERASE RICHARD WEINSHILBOUM Department of Pharmacology, Mayo Medical School/Mayo Graduate School/Mayo Clinic, Rochester, Minnesota of 6-TGNs measured in the RBC were correlated with both thiopurine therapeutic efficacy and toxicity such as myelosuppression (Lennard et al., 1983).
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The TPMT, RBC assay is used as a screen to detect individuals with low and intermediate TPMT activity who may be at risk for myelosuppression when exposed to standard doses of thiopurines, including azathioprine (Imuran) and 6-mercaptopurine (Purinethol). TPMT is the primary metabolic route for inactivation of thiopurine drugs in the bone marrow.
Human erythrocyte (RBC) TPMT activity is controlled by a common genetic polymorphism. Test Code 5700 Thiopurine Methyltransferase, RBC Alias. Prometheus TPMT Enzyme. Methodology. Enzymatic/Quantitative Liquid Chromatography-Tandem Mass Spectrometry. Specimen Requirements.